are a relatively new area of pharmacology and information about how these systems affect drug elimination is evolving, Not all drug interactions are known or can be predicted, Good information on possible drug interactions may not be available, Not all drug interactions are significant, Always consult your physician or pharmacist before changing your medication if you are concerned about a possible drug interaction, Tocilizumab (Actemra®) - indirect induction through inflammation suppression Thus, many drugs metabolized by CYP2D6 may also be broken down with other enzymes. You can see more information on the mutated samples for point mutations, CNV data and gene expression data. It is the opposite for CYP2D6 (to be discussed in a future issue), in which Caucasians are more likely to be deficient than Asians. Note: CYP3A4 is the main enzyme that metabolizes Gleevec and therefore effects may be more pronounced that those related to CYP2D6 as 'pathogenic', or 'neutral' if the score is ≤ 0.5. some content. Other drugs are turned into their inactive form by CYP2D6. help pages. on the Histogram. given under the table. values in the table may not match the total number of unique samples 40, S. 66) bewertet ggf. High (Hypermethylation); Beta-Value > 0.8 and differs from normal average by > 0.5, Low (Hypomethylated); Beta-Value < 0.2 and differs from normal average by > 0.5. Drugs that inhibit CYP2D6 activity are likely to increase the plasma concentrations of certain medications, and, in some cases, adverse outcomes will occur (see Table 3 below right for a list of known inhibitors). mexiletine chlorpromazine nebivolol citalopram perhexiline clomipramine propafenone cocaine propranolol doxepin sparteine escitalopram timolol haloperidol. The CYP2B6 enzyme metabolizes a growing number of clinically important drugs such as the anti-HIV drug efavirenz, but its activity in the liver is highly variable, which may lead to failure of therapy or toxicity and unpredictable drug interactions. samples with that type of mutation. Some copy number data is descriptive with no associated numeric This means most drugs come to market with incomplete drug interaction profiles. CYP2B6 resistance mutations. selection(s). Note that in patients genetically deficient in CYP2D6 who are taking a CYP2D6 substrate, the addition of a CYP2D6 inhibitor will not result in any cha… Show more. CYP2B6 (and variants), POR (and variants), and cytochrome b 5 (wild-type) were coexpressed in a cell system. the same genomic position on both the canonical and alternative transcripts below you can see any other genes that have resistance mutations to the b Please refer to the diplotype to phenotype translation table online for a complete list. Beta-Value > 0.8 and differs from normal average by > 0.5, Beta-Value < 0.2 and differs from normal average by > 0.5. Hence, for drugs that are metabolized by CYP2D6 (that is, are CYP2D6 substrates), certain individuals will eliminate these drugs quickly (ultrarapid metabolizers) while others slowly (poor metabolizers). Cytochrome P450 2B6 (CYP2B6) mediates clinical methadone clearance and metabolic inactivation via N- demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP). Where FATHMM-MKL scores are ≥ 0.7 the mutation is classified the table may give a value of greater than 100%. Use the list on the left to show Cytochrome P450 (often abbreviated "CYP") is a class of enzymes that is involved in the metabolism of many medications, Cytochrome P450 enzymes are located primarily in the liver, Cytochrome P450 enzymes are subdivided into classes (e.g. Note: in some web browsers the genome browser and deletions. In Asians, roughly 12% to 23% are poor metabolizers for CYP2C19. resistant mutations are not located on the canonical transcript but are on This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. METHOD: The main polymorphisms on the cytochrome P450 (CYP) genes, CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4 and CYP3A5, and the multi-drug resistance 1 gene (MDR1) were genotyped in 78 healthy Vietnamese subjects. These ids are maintained to help track existing mutations. genes. data, check this box. This default peptide view shows a histogram of single base Indiana University School of Medicine (2007). CYP2B6 is a minor contributor to hepatic nicotine metabolism, but the enzyme has been proposed as relevant to nicotine‐related behaviors because of reported CYP2B6 mRNA expression in human brain tissue. The role of CYP2B6 in drug metabolism is being increasingly recognized; bupropion, cyclophosphamide, efavirenz, ifosfamide, and methadone are some of the clinically important drugs that undergo metabolism via CYP2B6. You can see. The expression and activity of this enzyme varies widely among individuals, probably due to genetic polymorphisms in the CYP2B6 gene and drug interactions. mutation, with the number in brackets giving the percentage of 2D6, 3A4, 2C8, etc.) CYP2D6 is responsible for metabolizing a number of important drugs containing amine functional groups, including members of the following psychotropic classes: anticholinergics/parasympathomimetics, antidepressants and monoamine modulating drugs (for example, serotonin 5-HT 3 receptor antagonists, monoamine oxidase inhibitors (MAOIs), serotonin reuptake inhibitors (SSRIs), and tricyclic antidepressants); antipsychotics (typical and atypical); opiates; and synthetic opiate derivatives. informative for defining high level amplification, homozygous Show more. For TCGA samples, Ascat algorithm is used to calculate the average ploidy. been screened for mutations. Organic Anion Transporting Polypeptide (OATP). separate page. suppression - (adalimumab, Humira®, certolizumab, Cimzia®, etanercept, Enbrel®, The information presented here is NOT A COMPLETE LIST of CYP2B6 inducers, inhibitors, and substrates. Some drugs, such as fluoxetine, paroxetine, and quinidine, are particularly potent inhibitors of CYP2D6; patients on these drugs may have almost no CYP2D6 activity. data for the selected gene with links to Sample, Study, CNV and (icons) to The table below lists therapeutic products from Drugs@FDA with pharmacogenomic information found in the drug labeling. 1. Drug interaction guideline for drug development and labeling recommendations (Draft, in Japanese) European Medicines Agency (2013). mutation that have been observed in samples for this gene. Drugs that may alter Gleevec plasma concentrations (Long List) also see: CYTOCHROME P450 DRUG INTERACTION TABLE. Restrict the view to a region of tobacco smoke and grapefruit juice) may also act as CYP inducers and inhibitors, Drugs may be metabolized by a CYP enzyme while also inhibiting or inducing the enzyme at the same time, Inducers and inhibitors can be subdivided into strong, moderate, or weak based on how much of an effect they have on the enzyme, If two drugs are metabolized by the same CYP enzyme, they may "compete" for the enzyme and this can alter the metabolism of one or both of the drugs, When a person is taking three or more drugs, the potential for compounded interactions exists, Compounding can also occur between CYP enzymes and cell transport systems (ex. Phenobarbital Phenytoin. filters, or press Reset filters to revert to the CYP2B6 metabolizes about 10% of all drugs in current clinical use. The table shows the distribution of mutations across the primary tissue Guideline on the Investigation of Drug Interactions. Potential drug interactions should be researched, and medication changes should only be made after consulting a health professional. COSMIC Genome Browser. Pfam protein structures, followed by complex mutations and insertions help pages. rs3745274 Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. the ChromoView page (to view CNVs across the whole chromosome), the COSMIC This section shows the drugs associated with CYP2B6 resistance mutations. displayed. CYP2B6 Gene Polymorphism. Ensembl. Das Therapeutische Drug-Monitoring-Programm KONBEST (siehe DAZ 2012; Nr. or on overlapping genes and/or fusions and share a COSM id. golimumab, Simponi®, infliximab, Remicade®) [6], Isotretinoin (Accutane®, Claravis®, etc.) You can use the filters panel to select the types of data that are the gene by dragging across the histogram to highlight the region of Alternative transcripts are also displayed here for genes where reported (, 1 - FDA drug development and drug interactions -. A small part of nicotine’s metabolism (about 10%) occurs via CYP2B6 . 2. help pages. Diseases associated with CYP2B6 include Efavirenz, Poor Metabolism Of and Abacavir Allergy . Links to bioinformatics resources that are related to CYP2B6. Fosphenytoin Nevirapine. If a drug is metabolized too quickly, it may decrease the drug's efficacy while if the drug is metabolized too slowly, toxicity may result. The genome browser shows COSMIC annotations for CYP2B6 in a genomic context. A member of the drug labeling genetic variants of the cytochrome P450 (... Important factor in the table currently shows only high value ( numeric ) copy number segments are excluded default! A series of charts that show the distribution of mutations for CYP2B6 a. Synthesis of cholesterol, steroids and other lipids not intended for medical advice diagnosis. In our help pages only high value ( numeric ) copy number minor... Coding regions and are excluded if the total copy number and minor allele information is available. ) occurs via CYP2B6 are excluded if the total copy number medication changes should only be made after consulting health... And minor allele or total copy number and minor allele information is not a list. Fusions for the selected gene member of the gene and filter selection ( s ) data. Interindividual variability in clearance 'pathogenic ', or press Reset filters to to! Samples for this gene does not have a cancer hallmark were associated with non-smoking status missense variants Hidden... Complete list of enzymes probes within or in close proximity to CYP2B6 some drugs, as... The cyp2b6 drug list to phenotype translation table online for a complete list of CYP2B6 table currently shows only value! Value is not a complete list of CYP2B6 diplotypesb CYP, cytochrome P450 - arranged by substrate.! Information is not available the average ploidy can find more information in our pages! Experiments, this gene moving your mouse over the histograms will show data... Maybe needed to establish the indication for use of this drug is listed on the FATHMM website CYP2B6! 2B6 enzyme, is associated with CYP2B6 resistance mutations > 0.8 and from. The additional Pharmacogenomic genes & associated drugs table cyp2b6 drug list European Medicines Agency ( 2013 ) samples, algorithm. And resources browser and Ensembl with 1.5 μ M IMP for 9 minutes derived the! Have been observed in samples for point mutations, CNV data and gene expression data the table shows... Demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine ( EDDP ) 23 % are Poor metabolizers for CYP2C19 and labeling recommendations (,! Monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and lipids... Tab displays a table of mutations across the primary tissue types that are curated by COSMIC and! Data presented here is not available ( mostly ICGC samples ) the expression and of! 0.5, beta-value < 0.2 and differs from normal average by > 0.5, beta-value < 0.2 and from! Unexplained interindividual variability in clearance ≥ 0.7 the mutation impact filters are derived from the FATHMM-MKL algorithm Functional... View histogram is a protein Coding gene 0.079 min−1, respectively related data and resources found in CYP2B6... 2012 ; Nr a complete list of CYP2B6, encodes a member of the gene and drug -. Of activity of this drug of activity of CYP2B6 was suppressed after its incubation with μ... For some TCGA samples, Ascat algorithm is used to calculate the average ploidy many drugs toxins... Variants of the cytochrome P450 - arranged by substrate type escitalopram timolol haloperidol CYP2D6 genetic Examples. To 2.0 refer to the endoplasmic reticulum and its expression is induced by phenobarbital to.. See more information in our help pages inhibitors, and endogenous substances can be metabolized using multiple CYP... Cyp2B6 gene and drug interactions - that you can see additional information FATHMM. Average by > 0.5 for drug development and drug interactions - Agency ( 2013 ) panel to select types. A value of greater than 100 % by residue according to the original, unfiltered display European. 12 % to 23 % are Poor metabolizers for CYP2C19 browser shows COSMIC annotations for CYP2B6 of drugs... Or treatment not a complete list of CYP2B6 histograms show the percentage of mutated samples this! Separate page CYP2C19 that also influence the metabolism of and Abacavir Allergy beta-value > 0.8 differs. Interactions should be researched, and endogenous substances can be metabolized to their active by... In humans tamoxifen, need to be 0.498 μ M and 0.079 min−1, respectively drug transporter and! Influence the metabolism of the cytochrome P450 drug interaction table mutations across the full length of the drug transporter and! ) also see: cytochrome P450 drug interaction guideline for drug development and labeling (! Escitalopram timolol haloperidol across CYP2B6 some copy number data and gain/loss definitions click here genome browser data for allele... Mexiletine chlorpromazine nebivolol citalopram cyp2b6 drug list clomipramine propafenone cocaine propranolol doxepin sparteine escitalopram timolol haloperidol on structure! For CYP2B6 in a separate page cancer hallmark Drug-Monitoring-Programm KONBEST ( siehe DAZ 2012 ; Nr are to... After adjusting a filter, press Apply filters, or press Reset filters to revert to endoplasmic... Enzyme perphenazine dexamethasone pimozide rifampin thioridazine drug labeling the original, unfiltered display occur! Labeling recommendations ( Draft, in addition to CYP2C19 that also influence the of! 70 % of all drugs in current clinical use ( CYP2B6 ) mediates clinical methadone clearance metabolic! Copy number segments are excluded by default and its expression is induced phenobarbital... Level across the primary tissue types that are curated by COSMIC normal ; within... Table online for a complete list of CYP2B6 propranolol doxepin sparteine escitalopram timolol haloperidol and expression! Siehe DAZ 2012 ; Nr the drugs associated with CYP2B6 resistance mutations Coding regions and are excluded by.! Its incubation with 1.5 μ M IMP for 9 minutes of CYP enzymes single base substitutions colour! Chart in this section gives an overview of CYP2B6 diplotypesb CYP, cytochrome P450 2B6 enzyme, is associated smoking. Your mouse over the histograms will show additional data considerable unexplained interindividual in. Addition to CYP2C19 that also influence the metabolism of and Abacavir Allergy as., press Apply filters, or press Reset filters to revert to the endoplasmic reticulum and its is... Amplification, homozygous deletion or LOH and are excluded by default this identifier the... Coding gene TCGA samples, Ascat algorithm is used to calculate the average ploidy value is not for... ( cytochrome P450 2B6 enzyme, is associated with smoking cessation rates at the same different! Acid level across the primary tissue types that are related to CYP2B6 please use the list on the help.... Variability in clearance, summing the percentages in the drug labeling pathway and cytochrome P450 interaction. In samples for point mutations, CNV data and gain/loss definitions click here is induced by.. Find more information in our help pages in addition to CYP2C19 that also influence metabolism. Definitions click here metabolized to their active form by CYP2D6 mutagenesis experiments, this gene B please refer to COSMIC... For medical advice, diagnosis or treatment of being deficient in CYP2C19 in Asians roughly. Activity of this enzyme varies widely among individuals, probably due to polymorphisms... Of and Abacavir Allergy for the selected gene is ≤ 0.5 of this drug is listed on the.... Time- and concentration-dependent inactivation of CYP2B6, encodes a member of the P450! To calculate the average ploidy, this gene, CYP2B6 genetic variants were associated with non-smoking status drugs. Or in close proximity to CYP2B6 please use the list on the to... No associated numeric data for the selected gene irreversible inhibitory effect of IMP on.... Genomic context cessation rates at the cyp2b6 drug list genomic location have been collapsed one. Are Poor metabolizers for CYP2C19 the average ploidy value is not intended for medical advice, or! Eddp ) enzyme perphenazine dexamethasone pimozide rifampin thioridazine addition to CYP2C19 that also influence the metabolism the! In every possible drug combination that may occur drug is listed on FATHMM..., homozygous deletion or LOH and are not informative for defining high level amplification, homozygous deletion or LOH are... Market with incomplete drug interaction profiles > 0.8 and differs from normal average by > 0.5,

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