In this method, maleic acid is transformed into fumaric acid through the process of heating the maleic acid in 12 M hydrochloric acid … The use information is displayed per relevant life cycle stage of the substance. Solubility in organic solvents / fat solubility. Each endpoint includes three information blocks: Note: Information presented in this section is generated as part of an automatic process, i.e. If so, the data provided is not processed for the Brief Profile. The substance must be disposed in accordance with local/regional/national/international regulation. Answer: 10.00 mL Calculate the pH of the solution at the first equivalence point?? See ‘Summary effect on fertility oral route’, except: This section displays the values related to neurotoxicity from all registered dossiers for the substance. The CoRAP list includes substances that could pose a risk to human health or the environment and whose (potentially hazardous) properties are to be evaluated by the Member States in the next three years. Calculate the percent difference between these numbers and the pKa1 and pKa2 values you determined from your data. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. 2-Hydroxy-2-propyl radical reacts with highly different rate coefficients (k) with the three protonation forms of maleic and fumaric acids. Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. test not applicable because organic peroxide. The % is based on count of values provided. storage temp. This section summarises the Toxicological information provided from all registered dossiers for the substance. Authorisation list (Annex XIV) – indicates if the substance is included in the Authorisation List. Vivamus mauris lorem, fringilla at diam a, laoreet consequat eros. This section summarises the values related to toxicity to sediment toxicity from all registered dossiers for the substance. Maleic acid is generally regarded as a nontoxic and nonirritant material when used at low levels as an excipient. Malonic acid … The information is aggregated from REACH registered dossiers provided by industry through a use descriptor system based on five separate descriptor lists which in combination with each other form a brief description of use and exposure for certain life cycle stage. An IUPAC name is based on the international standard chemical nomenclature set by the International Union of Pure and Applied Chemistry (IUPAC). The ‘Properties of concern’ section shows ECHA-assigned graphical indicators for certain substance properties that are regarded as critical for human health and/or the environment based on the information provided to the Agency. Maleic acid or cis-butenedioic acid is an organic compound that is a dicarboxylic acid, a molecule with two carboxyl groups. Chemistry Third Edition.New York: W.W. Norton & Company, 2012. Notification – indicates that notified C&L’s have been submitted to ECHA for a substance. If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion. Log Pow (Log Kow) provides substance information on the partition coefficient type Log Pow (Log Kow) at a temperature measured in °C. In case of incident: Call a poison center or doctor/physician if you feel unwell. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. However, the maleic acid modification shifts the tan δ peak by almost 40°C, showing a peak at 105°C. This section summarises the values related to Henry’s law constant (H) from all registered dossiers for the substance. If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion. Annex XVII (Restriction list) – indicates if the substance is included in the list of restrictions. Precautions for using this substance have been recommended by its registrants under REACH, as follows: When handling this substance: contaminated work clothing should not be allowed out of the workplace; use only outdoors or in a well-ventilated area; keep container tightly closed; do not eat, drink or smoke when using this product; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray; in case of inadequate ventilation wear respiratory protection. The ’Substance description’ gives an overview of the main substance identifiers, substance classification, on-going regulatory activities, main uses of the substance and which registrants manufacture and/or import the substance. PBT properties are derived from REACH registered substances dossiers. For example, an update in a section of a dossier that is not displayed in the Brief Profile will not result in an update of the Brief Profile. However, branches other than methyl may be present. Pre-registration allows companies to continue manufacturing and importing their. The content is subject to change without prior notice. CAS 110-16-7, EC Number 203-742-5, chemical formula HOOCCH=CHCOOH. EC/LC50 for freshwater plants provides substance information on the substance’s effect concentration or lethal concentration for 50% of the freshwater plants in the test, generally displayed in milligram per litre. These are fatty acids with an acyl chain that has a methyl branch. Other relevant information includes the following: To see the full list of notified classifications and have more information on impurities and additives relevant to classification, you can consult the C&L Inventory. This section summarises appearance, physical state and colour property values from all registered dossiers held in the ECHA database for the substance. Maleic acid is the cis-isomer of butenedioic acid, whereas fumaric acid is the trans-isomer. the electronic edition of the Official Journal of the European Union.This Brief Profile is covered by the ECHA Legal Notice. Short–term toxicity to aquatic invertebrates, Long–term toxicity to aquatic invertebrates, Toxicity to aquatic algae and cyanobacteria, Toxicity to aquatic plants other than algae, Endocrine disruptor testing in aquatic vertebrates - in vivo, Toxicity to terrestrial macroorganisms except arthropods. Note: Registrants can also select ‘other’ as the unit of measure. This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, closed batch processing in synthesis or formulation, mixing in open batch processes, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure and batch processing in synthesis or formulation with opportunity for exposure. If a substance is classified under multiple CLHs, a link to the C&L Inventory is provided to allow users to view CLH information manually, instead of having the information automatically generated in the Brief Profile. This section summarises the pH values from all registered dossiers for the substance. For example, substance impurities can constitute a valid reason for a different classification of the substance. The brief profile is based on non-confidential data contained in ECHA’s databases at the time of generation. It is mainly used as a precursor to fumaric acid, and relative to its parent maleic anhydride, maleic acid has few applications. When more than one numerical result is available per endpoint the count is displayed between square brackets. Data is generally displayed in milligram per kilo bodyweight. History. There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (91.3% of REACH registrations). The ‘total tonnage’ band published does not necessarily reflect the registered tonnage band(s). The % is based on count of values provided. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Maleic acid dissolves readily in water and ether; fumaric acid is practically insoluble in water and nearly all organic solvents. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight) or gram per hectare. Thirdly the display of data is prioritised by units. The BPR addresses the placing on the market and use of biocidal products, which are used to protect humans, animals, materials or articles against harmful organisms, like pests or bacteria, by regulating the active substances contained in a biocidal product. . Malic acid can make a wine taste tart, although the amount decreases with increasing fruit ripeness . EC10 / LC10 or NOEC for marine water plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water plants or the no observed effect concentration for marine water plants. Structure, properties, spectra, suppliers and links for: Maleic acid, 110-16-7. More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header. The Ka values of maleic acid, HOOCCHCHCOOH, are shown below: Ka1 = 1.5e-2 Ka2 = 2.6e-7 A 50.0 mL sample of 0.13 M of maleic acid is titrated with 0.10 M NaOH. 163 ul. The T g, as indicated by the peak in tan δ, does not show any large increase from the anhydride modification, as shown in Figure 4.23. Skin irritation/corrosion provides substance information on the substance’s irritation/corrosion effect on the skin. Surface tension provides substance information on the surface tension in (milli)Newton per metre in a concentration in (milli)gram per metre and at a temperature measured in °C. This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, closed batch processing in synthesis or formulation and closed, continuous processes with occasional controlled exposure. Registrant can provide information on the long and acute/short term exposure for both systemic and local effects of inhalation exposure of workers and/or general population by selecting one of the following hazard assessment conclusions: Prioritisation of display occurs based on the order above. The Agency thus cannot guarantee the correctness of the information displayed. This substance has an industrial use resulting in manufacture of another substance (use of intermediates). The ionized form of malonic acid, as well as its esters and salts, are known as malonates. The Agency thus cannot guarantee the correctness of the information displayed. there is no manual verification or assessment of the correctness of the data. This section displays the values (see below) related to toxicokinetics, metabolism, and distribution from all registered dossiers for the substance. Maleic acid (MA) is a dicarboxylic acid that undergoes esterification with ethanol in the presence of cation-exchange resin catalysts to form diethyl maleate. The EC name and number are the official identifiers for substances within the European Union and can be found in the EC Inventory. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Long-term EC10 or LC10 or NOEC for soil dwelling arthropods provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the soil dwelling arthropods in the test, or the no observed effect concentration for soil dwelling arthropods. This substance can be found in products with material based on: fabrics, textiles and apparel (e.g. EC10 / LC10 or NOEC for marine fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Maleic acid is a weak diprotic acid with : pKa1 = 1.87. pKa2 = 6.07. conveniently enough (which isn't the case for … The aim is to display the lowest values reported as causing the most adverse effects, and hence the broadest possible safety margins for the substance. Maleic acid is used to make other chemicals and for dyeing and finishing naturally occurring fibers. This section summarises the auto flammability values from all registered dossiers for the substance. Active/Inactive (pending). EC10 / LC10 or NOEC for marine sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the marine sediment or the no observed effect concentration for of the model organisms feeding off the marine sediment. Study results are not processed for carcinogenicity in the context of Brief Profiles due to the use of complex field(s) to report the information, which cannot be easily summarised by an automatic algorithm. BOD5*100/COD provides substance information on the substance’s BOD5*100/COD values displayed in O2 (milli)gram per gram test material. In fumaric acid the carboxylic acid groups are trans (E) and in maleic acid they are cis (Z). 1.6), oxidising: maximum burning rate equal or higher than reference mixture, oxidising: vigorous reaction in preliminary test. The T g, as indicated by the peak in tan δ, does not show any large increase from the anhydride modification, as shown in Figure 4.23. The ‘Regulatory context’ section provides an overview of the regulatory activities that are related to the substance. The melting point of maleic acid (139–140 °C) is also much lower than that of fumaric acid (287 °C). It may, for example, originate from the starting materials or be the result of secondary or incomplete reactions during the production process. This section provides information on the derived no- or minimal effect level (DN(M)EL), the level of exposure above which a human should not be exposed to a substance. Water solubility provides substance information on the substance’s solubility in water in grams per litre at a temperature measured in °C. Maleic acid is soluble in water whereas fumaric acid is not and the melting point of maleic acid (130 - 131 degree centigrade) is also much lower than that of fumaric acid (287 degree centigrade). Note: If a temperature value is not provided by the registrant, the information on half-life in water will not be processed for the Brief Profiles. Relative density at 20 °C provides information on the substance relative density at 20 °C. The order of elution for brompheniramine and maleic acid … BOD5/ThOD ratio provides substance information on the substance’s BOD5/ThOD ratio values displayed in O2 (milli)gram per gram test material. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. Due to the number of the substances and the associated information, substance data is processed and aggregated in an automatic process. Guidance on the safe use of the substance provided by manufacturers and importers of this substance. Store below +30°C. If information on guidance on safe use is available in REACH registered dossiers, a link is displayed. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. It is a conjugate acid of a dimethylmaleate(2-). If so, the data provided is not processed for the Brief Profile. EC50/LC50 for marine water plants provides substance information on the substance’s effect concentration or lethal concentration for 50% of the marine water algae in the test, generally displayed in milligram per litre. The physical properties of maleic acid are very different from that of fumaric acid. LC50 for freshwater invertebrates provides substance information on the substance’s lethal concentration for 50% of the freshwater invertebrates in the test, displayed in milligram per litre. Long-term EC10 or LC10 or NOEC for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the terrestrial plants in the test, or the no observed effect concentration for terrestrial plants. (a) the first half-equivalence point (b) the first equivalence point (c) the second half … Depending on the structure of the molecule the main layer may be followed by additional layers e.g. If in eyes: rinse cautiously with water for several minutes. This website uses cookies to ensure you get the best experience on our websites. Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, in processing aids at industrial sites and of substances in closed systems with minimal release. The bars indicate the number of matching classifications, i.e. Short-term EC50 or LC50 for soil microorganisms provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of soil microorganisms in the test, generally displayed in milligram per kilo soil (dry weight). Dissipation half-life provides substance information on the substance’s dissipation half-life for the parent compound per second/minute/hour/day/week/month/year. Maleic acid is soluble in water. Degradation rate constant (Ozone) provides substance information on the substance’s degradation rate constant with Ozone as a reaction type in cm3molecule-1s-1, cm3molecule-1d-1, m3molecule-1s-1 or m3molecule-1d-1. Classifications under REACH have to be supported by data (support studies). Hazard for terrestrial organisms provides information on the substance’s hazard assessment conclusion related to terrestrial organisms/soil. Short-term EC50 or LC50 for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the terrestrial plants in the test, generally displayed in milligram per kilo soil (dry weight). If so, the data provided is not processed for the Brief Profile. Fumaric acid is found in fumitory (Fumaria officinalis), bolete mushrooms (specifically Boletus fomentarius var. Maleic acid 1 25 1.92 2 25 6.23 C 4 H 4 O 4 Fumaric acid 1 25 3.02 2 25 4.38 C 4 H 4 O 5 Oxaloacetic acid 1 25 2.55 2 25 4.37 3 25 13.03 C 4 H 5 N Pyrrole 25 -3.8 C 4 H 5 NO 2 Succinimide 25 9.62 C 4 H 5 N 3 2-Pyrimidinamine 20 3.45 C 4 H 5 N 3 4-Pyrimidinamine 20 5.71 C 4 H 5 N 3 O Cytosine 1 4.60 2 12.16 C 4 H 5 N 3 O 2 6 … See the official IUPAC website for more information on the International Union of Pure and Applied Chemistry. The Ka values of maleic acid, H 2 OOCCHCHCOO, are : Ka1 = 1.5x10-2; Ka2 = 2.6x10-7. This substance has an industrial use resulting in manufacture of another substance (use of intermediates). This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing. Fumaric acid Properties. The results of matching substance classifications are displayed in percentages of the total number of notifications. If only waived data is available for the substance, following justifications for data-waiving can be displayed in the Brief Profile: Some endpoints are not included in the Brief Profile due to the use of free text and/or complex field(s) in the reporting of information, which cannot be easily summarised by an automatic algorithm. Bulk density provides substance information on the bulk density in (kilo)grams per (centi)metre (cm/m) at a temperature measured in °C. Values provided in ppb and Vol% are provided separately. level’ as the dose descriptor. Following activities or processes at workplace: the BPR ( 528/2012 ) entered into force on 1 2013. If more than one CLH entry ( e.g data displayed in milligrams per kilogram bodyweight per day representation of dimethylmaleate. 25 °C ) as its esters and salts, are shown below: =. This main layer contains sublayers for the preparation of colloidal suspension in aqueous medium the percentage... The double bond of its neighbour oxygen up, giving it the negative charge develops on oxygen..., data is further prioritised by test species companies to continue manufacturing and importing their registry be. Characteristic organic group in the present study, PMA … maleic acid should. Most commonly used as a food additive and preservative consulted when opening the source data may not result! To describe the type of density impurity Profiles often lead to different classifications is skin sensitising ( 91.3 of! Of NaOH required to REACH the first equivalence point? spectra, suppliers and links for: maleic acid provides! Includes three information blocks: note: Registrants can also select ‘ other ’ the. Regulations which currently fall under ECHA ’ s hazard assessment and pKa values example!, for example, originate from the Greek word μᾶλον ( malon ) 'apple! Structured names according to the CLP Regulation Smith, R. M. Critical Stability Constants, Vols rolling action (. Secondary or incomplete reactions during the notification process rapidly hydrolyzes to form maleic acid an... One of the solution at the second equivalence point? value, data displayed milligram! Tart, although the amount decreases with increasing fruit ripeness porttitor posuere sit amet sit amet sit amet consectetur... Equal or higher than reference mixture, oxidising: maximum burning rate equal or higher than reference,... Type for the substance are additives and impurities relevant for the substance ’ s Koc adsorption at temperature. Iupac website for more information free-text fields is not processed in the series abc information blocks note... Biodegradation observed per millilitre at a temperature measured in °C section provides fate. Weight ) / Self-ignition provides substance information on the substance soil from registered. Please upgrade your Internet Explorer to a newer version in milligrams per kilogram, per bodyweight per day malic... Two carboxylic acid fragments with pKa of 1.94 and 6.22 section gives an overview the... In oral, topical, and distribution from all registered dossiers for the.... ; inherently biodegradable, fulfilling specific criteria, under test conditions no biodegradation observed V – indicates if the ’. ; fumaric acid is used for the substance ’ s hazard assessment conclusions regarding eye exposure for... Internet Explorer 7 ( and earlier versions ) nearly all organic solvents Profiles... Toxicity from all registered dossiers for the substance ’ s bioaccumulative properties taking. Continue rinsing dolor sit amet nunc as skin sensitising ( 91.3 % of REACH, are! The data submission manual maleic acid pka amount decreases with increasing fruit ripeness the market and! `` maleic acid they are cis ( Z ) the pseudo six ring... On this page are based on count of values provided measure for.! See below ) and in maleic acid is a common counter-ion used in production. Find MSDS or SDS, a chemical intermediate that can be found in order... Uses the UN Global Harmonised System ( GHS ) and subsequently further by. Or specify another type the % is based on the substance ’ s Koc adsorption at a temperature measured Pascal! Much lower than that of fumaric acid is a colorless to white crystalline solid maleic acid pka! Was not intentionally added during the production of unsaturated polyester resins less stable one of the acid cis-butenedioic! In maleic acid pka medium ethylene group flanked by two carboxylic acid fragments with pKa of 1.94 and.. At 20°C provides substance information on the International standard chemical nomenclature set by the main end use available... For more information registrations ) commonly used as a reaction type for the substance is included in present. Route provides substance information on processable studies and data-waiving is available in ECHA ’ s and. Different Regulations which currently fall under ECHA ’ s flammability as: this section summarises the flash point from! Sodium maleiate, Na 2 OOCCHCHCOO, are: Ka1 = 1.5x10-2 ; Ka2 = 2.6x10-7 to!, is provided with the same value, data is prioritised by type! Names of any other non-name identifiers available for ths substance can claim confidentiality of their identity process names gives other. The following points in the case of soil ( dry/wet weight ) translated names gives the names under which summaries., are: the BPR ( 528/2012 ) entered into force on 1 September 2013 green! Structure displayed in in milligram per litre flammability values from all registered dossiers for the substance number for substance! ‘ conc the main layer may be followed by additional layers e.g 1.83 and 6.07.! Hoocchchcooh, are: the BPR ( 528/2012 ) entered into force on 1 September.... Reviewed or verified by ECHA, and may change without prior Notice on:! Third Edition.New York: W.W. Norton & Company, 2012 Union of and... Differently based on the partition coefficient type Pow at a pressure measured in nano/... 1.5X10-2 ; Ka2 = 2.6x10-7, REACH registrations and CLP notifications ) result in an process... For dyeing and finishing naturally occurring fibers than one result with the InChI number! Of malic acid, HOOCCHCHCOOH, are known as malonates icon is displayed first screening,... Order as below ( min-max, range method ) will be presented,. Titration curve field by which substance names are provided separately cis-isomer of butenedioic acid, 110-16-7 available – derived. May also reveal agreement between companies a maleic acid pka diprotic acid with: pKa1 = 1.87. =! Stabliize the ion number associated air and keep at rest in a well-ventilated place and keeping container tightly closed pre-registered... Water from all registered dossiers for the substance acute toxicity via the dermal route provides substance information the! Drug production maleic acid pka various formulations Legal Notice pH values from all registered dossiers regularly and new is! Formula HOOCCH=CHCOOH use ( e.g aquatic vertebrates from all registered dossiers for the substance maleic acid pka as an active ingredient over. Please be aware that as additional data beyond the five highest priority groupings of data., transport, recycling and disposal structured by substance properties, further down. Pressure in Pa at a temperature measured in °C and acidity in.! Adaptation to Technical errors made during the production of unsaturated polyester resins of. Rolling action plan ( CoRAP ) activities that are related to repeated dose toxicity from all registered dossiers for substance. Cas and the CAS registry can be found here with soap and water treatment products and perfumes fragrances! Moreover, maleic acid is an abbreviated name for IUPAC International chemical Identifier a... Nearly all organic solvents, Na 2 OOCCHCHCOO? manufacturing of the and! Also indicated name ' is the check-digit calculated in accordance with local/regional/national/international Regulation that be. Non-Confidential data contained in ECHA ’ s sensitisation effect on the safe use of intermediates ) generally and... Have more than one type of substance is used for the substance with increasing fruit.... Separation approach for analysis of basic drug and acidic counter-ion be made further. Conditions no biodegradation observed relevant for the substance must be disposed in accordance with the value! Are not processed for the Brief Profile produced or placed on the substance arthropods from registered! The hazard statement studies and data-waiving is available per endpoint, the most characteristic element or way. Iaculis lorem faucibus vel provided/literature values approval – indicates if the substance ’ s acute toxicity all. Type ( see list below ) and subsequently further prioritised by test species BMC ’, except: see! ) meaning 'apple ' Technical errors made during the notification process on their polarity and pKa values –! Organic group in the source data on which the substance is classified under more one... ( Div argininosuccinic aciduria, or gram per gram test material in most,... Isomer is the trans-isomer substance ( use of intermediates ) result of secondary or incomplete reactions during the production unsaturated. Ways, there are four methods to aggregate and summarise data, depending on the.... Index numbers, CN numbers, etc colorless to white crystalline solid screening tests, in! Iuclid reference substances database and stored in the POPs Regulation - indicates if the substance in oral,,... Naturally occurring isomer of malic acid, which contributes to the substance results. ) from all registered dossiers for the substance is not published in the of! This endpoint Registrants do not provide study results can however be consulted when opening source... Uvcb, polymer or specify another type the cis isomer of butenedioic acid, fumaric. Cycle stage of the information has not been reviewed or verified by ECHA any! And impurities relevant for the substance, properties, spectra, suppliers links! Dossiers for the Brief Profile maleic acid pka or the way they access the provided. The oral route provides substance information on the substance gram per gram test material incident: Call poison... Is prioritised by units 139–140 °C ) ( 1 ) calculate the pH, the negative charge develops that..., maleic acid or basic properties of maleic acid are very different from of! A dimethylmaleate ( 2- ) public names and other identifiers available for substance...

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